RN 1747

Tocris Bioscience | Catalog # 3745

Selective TRPV4 agonist
Tocris Bioscience
Discontinued Product
3745 has been discontinued. View all TRPV Agonists products.

Key Product Details

Description

Selective TRPV4 agonist
View all TRPV Agonists »

Product Description

RN 1747 is a selective TRPV4 agonist (EC50 values are 0.77, 4.0 and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively). Displays selectivity over other TRP channels (EC50 values are 0.77, >30, >30 and >100 μM for TRPV4, TRPM8, TRPV3 and TRPV1 receptors respectively). Also antagonizes TRPM8 at relevant concentrations (IC50 = 4 μM).

Product Specifications for RN 1747

Molecular Weight

395.87

Formula

C17H18ClN3O4S

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

1-(4-Chloro-2-nitrophenyl)sulfonyl-4-benzylpiperazine

CAS Number

1024448-59-6

PubChem ID

5068295

InChI Key

ZNLVYSJQUMALEO-UHFFFAOYSA-N

SMILES

ClC1=CC=C(S(N2CCN(CC3=CC=CC=C3)CC2)(=O)=O)C([N+]([O-])=O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.59 100

Preparing Stock Solutions for RN 1747

The following data is based on the product molecular weight 395.87.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.53 mL 12.63 mL 25.26 mL
5 mM 0.51 mL 2.53 mL 5.05 mL
10 mM 0.25 mL 1.26 mL 2.53 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 11 publications citing the usage of this product.

Product Documents for RN 1747

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RN 1747

For research use only

Related Research Areas

Ion Channels and Regulators

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