Ro 08-2750

Key Product Details

Product Description

Ro 08-2750 is a non-peptide inhibitor of NGF that binds the NGF dimer (K_D ~ 1 μM) possibly causing a conformational change. Selectively inhibits binding of NGF to p75^NTR at submicromolar concentrations, and to both p75^NTR and TrkA at concentrations > 5 μM. Prevents NGF-induced apoptosis in SK-N-MC cells. Suppresses cancer cell proliferation via regulation of Hippo signaling aand YAP phosphorylation.

Product Specifications for Ro 08-2750

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ro 08-2750

The following data is based on the product molecular weight 270.24.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	37.00 mL	185.02 mL	370.04 mL
0.5 mM	7.40 mL	37.00 mL	74.01 mL
1 mM	3.70 mL	18.50 mL	37.00 mL
5 mM	0.74 mL	3.70 mL	7.40 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

• Arkin and Wells Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat.Rev.Drug Discov. 2004 PMID: 15060526
• Yang NTRK1 is a positive regulator of YAP oncogenic function. Oncogene 2018 PMID: 30542115
• Niederhauser NGF ligand alters NGF signaling via p75NTR and TrkA. J.Neurosci.Res. 2000 PMID: 10900073

Product Documents for Ro 08-2750