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Ro 106-9920

Catalog #: 1778
4 Citations Datasheet / COA / SDS

Discontinued Product

1778 has been discontinued.
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Ro 106-9920 | CAS No. 62645-28-7 | NFkB/IkB Inhibitors
1 Image
Description: Inhibitor of NF-κB activation

Chemical Name: 6-(Phenylsulfinyl)tetrazolo[1,5-b]pyridazine

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Ro 106-9920 is an inhibitor of NF-κB activation, possibly via selective inhibition of LPS- and TNF-α-induced IκBα ubiquitination (IC50 = 3 μM). Blocks subsequent production of TNF-α, IL-1β and IL-6. Inhibits mucin production in an in vitro model of COPD, and is anti-inflammatory following oral administration in vivo. Also weakly inhibits EGFR, 5-lipoxygenase and iNOS.

Technical Data

M.Wt:
245.26
Formula:
C10H7N5OS
Solubility:
Soluble to 5 mM in ethanol and to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
62645-28-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Anticancer agents. XII. Pyridazine and benzodiazine derivatives.
    Conalty et al.
    Proc.R.Ir.Acad.B., 1976;76:151
  2. A small molecule ubiquitination inhibitor blocks NF-κB-dependent cytokine expression in cells and rats.
    Swinney et al.
    J.Biol.Chem., 2002;277:23573
  3. Glucocorticoid modulation of MUC5AC secretion in H292 cells.
    Baginski et al.
    Am.Soc.Cell Biol.Abstr., 2002;:765

Product Datasheets

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Citations for Ro 106-9920

The citations listed below are publications that use Tocris products. Selected citations for Ro 106-9920 include:

4 Citations: Showing 1 - 4

  1. Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease.
    Authors: Siew Et al.
    Nat Commun  2019;10:3473
  2. ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells.
    Authors: Huang Et al.
    J Inflamm (Lond)  2015;12:31
  3. Ligand engagement of Toll-like receptors regulates their expression in cortical microglia and astrocytes.
    Authors: Marinelli Et al.
    PLoS One  2015;12:244
  4. Regulation of neutrophil extracellular trap formation by anti-inflammatory drugs.
    Authors: Lapponi Et al.
    J Pharmacol Exp Ther  2013;345:430

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