Ro 26-4550 trifluoroacetate

Key Product Details

Product Description

Competitive reversible inhibitor of interleukin-2 (IL-2) binding to its receptor (IC₅₀ = 3 μM for inhibition of IL-2 interaction with IL-2R α-subunit). Appears to compete with IL-2Rα for its binding site on IL-2.

Product Specifications for Ro 26-4550 trifluoroacetate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Ro 26-4550 trifluoroacetate

The following data is based on the product molecular weight 560.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	3.57 mL	17.84 mL	35.68 mL
2.5 mM	0.71 mL	3.57 mL	7.14 mL
5 mM	0.36 mL	1.78 mL	3.57 mL
25 mM	0.07 mL	0.36 mL	0.71 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Tilley Identification of a small molecule inhibitor of the IL-2/IL-2Rα receptor interaction which binds to IL-2. J.Am.Chem.Soc.
• Braisted Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. J.Am.Chem.Soc. 2003 PMID: 12656598

Product Documents for Ro 26-4550 trifluoroacetate