RO-275

Key Product Details

Product Description

RO-275 is a potent and selective HCN1 (hyperpolarization-activated cyclic-nucleotide-gated channel 1) inhibitor (IC₅₀ = 46 nM). It shows <100-fold selectivity over HCN2, HCN3 and HCN4. In vivo, RO-275 improves performance in a translationally relevant touchscreen task of working memory (TUNL) in rats. RO-275 is orally bioavailable and brain-penetrant.

Licensing Information

This compound is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the RO-275 probe summary on the SGC website.

Product Specifications for RO-275

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RO-275

The following data is based on the product molecular weight 351.79.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.69 mL	28.43 mL	56.85 mL
2.5 mM	1.14 mL	5.69 mL	11.37 mL
5 mM	0.57 mL	2.84 mL	5.69 mL
25 mM	0.11 mL	0.57 mL	1.14 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Harde Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory. Cell.Chem.Biol. 2024 PMID: 38042151

Product Documents for RO-275