RO 4929097

Tocris Bioscience | Catalog # 8906

Potent and selective γ-secretase inhibitor; also induces differentiation of iEM cells into luminal cells
Tocris Bioscience
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Key Product Details

Description

Potent and selective γ-secretase inhibitor; also induces differentiation of iEM cells into luminal cells

Alternative Names

RG-4733
View all gamma-Secretase inhibitors »

Product Description

RO 4929097 is a potent and selective γ-secretase inhibitor (IC50 = 4 nM), exhibiting over 100-fold selectivity against a panel of 75 different proteins. Inhibits cellular processing of Notch and Aβ40 (IC50 = 5 nM and 14 nM, respectively). In tumor cells, inhibition of Notch processing results in lowered expression of HES1. In multiple xenograft models, RO 4929097 displays antitumour effects with no associated body weight loss or Notch-related toxicities. In melanoma cell lines, it inhibits tumor formation and blocks invasive growth pattern of metastatic melanoma. Can also be used to induce differentiation of iEM cells into luminal cells. Orally bioavailable.

Product Specifications for RO 4929097

Molecular Weight

469.41

Formula

C22H20F5N3O3

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2,2-Dimethyl-N-((S)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide

CAS Number

847925-91-1

PubChem ID

49867930

InChI Key

OJPLJFIFUQPSJR-INIZCTEOSA-N

SMILES

O=C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O)C(C)(C)C(NCC(F)(F)C(F)(F)F)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.47 50
Ethanol 23.47 50

Preparing Stock Solutions for RO 4929097

The following data is based on the product molecular weight 469.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.26 mL 21.30 mL 42.61 mL
2.5 mM 0.85 mL 4.26 mL 8.52 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
25 mM 0.09 mL 0.43 mL 0.85 mL

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Product Documents for RO 4929097

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RO 4929097

For research use only

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