Roxindole hydrochloride

Tocris Bioscience | Catalog # 1559

Dopamine D2 autoreceptor agonist. Also has affinity for D3, D4, 5-HT1A receptors and the 5-HT transporter
Tocris Bioscience
Discontinued Product
1559 has been discontinued. View all Non-selective Dopamine Receptor Agonists products.

Key Product Details

Description

Dopamine D2 autoreceptor agonist. Also has affinity for D3, D4, 5-HT1A receptors and the 5-HT transporter

Alternative Names

EMD 49980
View all Non-selective Dopamine Receptor Agonists »

Product Description

Roxindole hydrochloride is a dopamine D2 autoreceptor agonist, with affinity for D3, D4 and 5-HT1 receptors (pKi values are 8.55, 8.93, 8.23, 9.42, 6.00 and 7.05 for human D2, D3, D4, 5-HT1A, 5-HT1B and 5-HT1D receptors). Inhibits 5-HT uptake and is antidepressant in vivo.

Product Specifications for Roxindole hydrochloride

Molecular Weight

382.93

Formula

C23H26N2O.HCl

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-ol hydrochloride

CAS Number

108050-82-4

PubChem ID

9886286

InChI Key

ZCEPVNSWLLJECX-UHFFFAOYSA-N

SMILES

OC(C=C4)=CC1=C4NC=C1CCCCN2CCC(C3=CC=CC=C3)=CC2.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 19.15 50 with gentle warming

Preparing Stock Solutions for Roxindole hydrochloride

The following data is based on the product molecular weight 382.93.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.22 mL 26.11 mL 52.23 mL
2.5 mM 1.04 mL 5.22 mL 10.45 mL
5 mM 0.52 mL 2.61 mL 5.22 mL
25 mM 0.10 mL 0.52 mL 1.04 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for Roxindole hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Roxindole hydrochloride

For research use only

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