RP 67580

Key Product Details

Product Description

RP 67580 is a potent and selective tachykinin NK₁ receptor antagonist (K_i values are 2.9 nM and > 10 μM for rat NK₁, and rat NK₂ and NK₃ receptors respectively). Displays higher affinity at rat and mouse than human receptors. Antinociceptive in vivo, possibly partly via inhibition of calcium channels.

Product Specifications for RP 67580

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RP 67580

The following data is based on the product molecular weight 438.57.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.28 mL	11.40 mL	22.80 mL
5 mM	0.46 mL	2.28 mL	4.56 mL
10 mM	0.23 mL	1.14 mL	2.28 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 66 publications citing the usage of this product.

• Rupniak Antinociceptive activity of NK₁ receptor antagonists: non-specific effects of racemic RP67580. Br.J.Pharmacol. 1993 PMID: 8306108
• Fong Molecular basis for the species selectivity of the neurokinin-1 receptor antagonists CP-96,345 and RP67580. J.Biol.Chem. 1992 PMID: 1281470
• Garret Pharmacological properties of a potent and selective nonpeptide substance P antagonist. Proc.Natl.Acad.Sci.U.S.A. 1991 PMID: 1719549
• Beaujouan Higher potency of RP 67580, in the mouse and the rat compared with other nonpeptide and peptide tachykinin NK₁ antagonists. Br.J.Pharmacol. 1993 PMID: 7682138

Product Documents for RP 67580