RS 25344 hydrochloride

Tocris Bioscience | Catalog # 3315

Potent PDE4 inhibitor
Tocris Bioscience
Discontinued Product
3315 has been discontinued. View all Phosphodiesterase Inhibitors products.

Key Product Details

Description

Potent PDE4 inhibitor
View all Phosphodiesterase Inhibitors »

Product Description

Potent and selective phosphodiesterase (PDE) 4 inhibitor (IC50 values are 0.28, > 100, 160 and 330 nM at PDE4, PDE1, PDE2 and PDE3 respectively). Inhibits eosinophil chemotaxis and increases progressive motility of spermatozoa in vitro.

Product Specifications for RS 25344 hydrochloride

Molecular Weight

411.80

Formula

C19H13N5O4.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

1-(3-Nitrophenyl)-3-(4-pyridinylmethyl)-pyrido[2,3-d]pyrimidine-2,3-(1H,3H)-dione hydrochloride

CAS Number

152815-28-6

PubChem ID

19781728

InChI Key

ROSFKXDQMBPYQQ-UHFFFAOYSA-N

SMILES

O=C(N(CC4=CC=NC=C4)C2=O)N(C3=CC([N+]([O-])=O)=CC=C3)C1=C2C=CC=N1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.59 50
DMSO 41.18 100

Preparing Stock Solutions for RS 25344 hydrochloride

The following data is based on the product molecular weight 411.80.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.14 mL 24.28 mL
5 mM 0.49 mL 2.43 mL 4.86 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 13 publications citing the usage of this product.

Product Documents for RS 25344 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RS 25344 hydrochloride

For research use only

Citations for RS 25344 hydrochloride

Customer Reviews for RS 25344 hydrochloride

There are currently no reviews for this product. Be the first to review RS 25344 hydrochloride and earn rewards!

Have you used RS 25344 hydrochloride?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card