(RS)-3,5-DHPG

Tocris Bioscience | Catalog # 0342

Selective group I mGlu agonist
Tocris Bioscience

Key Product Details

Description

Selective group I mGlu agonist
View all Group I mGluR Agonists »

Product Description

(RS)-3,5-DHPG is a selective group I metabotropic glutamate receptor agonist which activates both mGlu1 and mGlu5. Also reported to be an antagonist at metabotropic glutamate receptors linked to phospholipase D.

S-enantiomer also available.

Product Specifications for (RS)-3,5-DHPG

Molecular Weight

183.16

Formula

C8H9NO4

Storage

Desiccate at -20°C

Purity

≥99% (HPLC)

Chemical Name

(RS)-3,5-Dihydroxyphenylglycine

CAS Number

146255-66-5

PubChem ID

108001

InChI Key

HOOWCUZPEFNHDT-UHFFFAOYSA-N

SMILES

NC(C(O)=O)C1=CC(O)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.83 10

Preparing Stock Solutions for (RS)-3,5-DHPG

The following data is based on the product molecular weight 183.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 54.60 mL 272.99 mL 545.97 mL
0.5 mM 10.92 mL 54.60 mL 109.19 mL
1 mM 5.46 mL 27.30 mL 54.60 mL
5 mM 1.09 mL 5.46 mL 10.92 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 80 publications citing the usage of this product.

Product Documents for (RS)-3,5-DHPG

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (RS)-3,5-DHPG

For research use only

Customer Reviews for (RS)-3,5-DHPG (4)

4.8 out of 5
4 Customer Ratings
5 Stars
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4 Stars
25%
3 Stars
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1 Stars
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Showing  1 - 4 的 4 reviews Showing All
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  • Test of potential modulation of 5HT-1B receptor effects
    Name: Sergiy Sylantyev
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: Arcuate nucleus
    Verified Customer | Posted 12/10/2023
    (RS)-3,5-DHPG was used to test a (potential) impact of metabotropic glutamate receptors on the effect of 5HT-1B receptors on neurotransmitter vesicle release in interneuronal synapse. Picture: membrane capacitance fluctuation of living neuron after series of electrical stimuli delivered to acute neural tissue. Left: control. Right: activation of metabotropic glutamate receptors (with 1 μM CHPG, 1 μM (RS)-3,5-DHPG and 1 μM AMN 082), GABA-B receptors and ACh receptors does not show a significant effect. Grey traces: individual recordings; red: averaged trace.
    (RS)-3,5-DHPG 0342
  • Using (RS)-3,5-DHPG in slice ephys recordings
    Name: Estela Correa
    Species: Mouse
    Assay Type: Ex Vivo
    Verified Customer | Posted 12/06/2023
    Dissolved in MilliQ H2O, and used at a concentration of 0.1 mM.
    I used (RS)-3,5-DHPG (Cat. No. 0342) in slice ephys recordings. Worked as expected.
  • mGluR antagonism with bath application
    Name: Anonymous
    Assay Type: In Vitro
    Cell Line/Tissue: Organotypic Hippocampus Slices
    Verified Customer | Posted 10/20/2017
    Bath application on brain slice. Publication in progress.
  • (RS)-3,5-DHPG application in brain slice preparation
    Name: Anonymous
    Assay Type: Ex Vivo
    Verified Customer | Posted 07/17/2017
    (RS)-3,5-DHPG is light and air sensitive and is not stable in alkaline solutions. It is best to use aliquots within a week. Aliquots should not have a brown coloration under proper storage conditions.
    (RS)-3,5-DHPG was bath applied and also pressure ejected at a concentration of up to 200 μM in a mouse brainstem slice preparation during whole-cell and perforated patch clamp. Results were consistent across different batch #s of (RS)-3,5-DHPG.

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