RS 79948 hydrochloride

Key Product Details

Product Description

RS 79948 hydrochloride is a α₂-adrenoreceptor antagonist (K_d values are; 0.18, 0.19 and 0.42 nM for α_2B α_2C and α_2A, respectively in rat).

Licensing Information

Sold with the permission of Roche Bioscience

Product Specifications for RS 79948 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RS 79948 hydrochloride

The following data is based on the product molecular weight 400.96.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	9.98 mL	49.88 mL	99.76 mL
1.25 mM	2.00 mL	9.98 mL	19.95 mL
2.5 mM	1.00 mL	4.99 mL	9.98 mL
12.5 mM	0.20 mL	1.00 mL	2.00 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

• Hume Evaluation in rat of RS-79948-197 as a potential PET ligand for central α₂-adrenoceptors. Eur.J.Pharmacol. 1996 PMID: 8982721
• Uhlen [³H]RS79948-197 binding to rat, guinea pig and pig α_2A-, α_2B and α_2C-adrenoceptors. Comparison with MK912, RX821002, rauwolscine and yohimbine. Eur.J.Pharmacol. 1998 PMID: 9551719
• Clark (8aα,12aα,13aα)-5,8,8a,9,10,11,12,12a,13,13a-Decahydro-3-methoxy-12-(ethylsulphonyl)-6H-isoquino[2,1-g][1,6]-naphthyridine, a potent and highly selective α₂-adrenoceptor antagonist. J. Med. Chem. 1989 PMID: 2570150

Product Documents for RS 79948 hydrochloride