Rupintrivir

Key Product Details

Product Description

Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC₅₀ = 5 nM). Exhibits no significant inhibition against a variety of serine and cysteine proteases. Inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays.

Tocris products are for biomedical research use only. They are not intended for human or veterinary use.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Rupintrivir

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rupintrivir

The following data is based on the product molecular weight 598.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.67 mL	8.35 mL	16.70 mL
5 mM	0.33 mL	1.67 mL	3.34 mL
10 mM	0.17 mL	0.84 mL	1.67 mL
50 mM	0.03 mL	0.17 mL	0.33 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Dragovich Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J.Med.Chem. 1999 PMID: 10197964
• Patick In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob.Agents Chemother. 1999 PMID: 10508022

Product Documents for Rupintrivir