RWJ 50271

Tocris Bioscience | Catalog # 4227

Inhibitor of LFA-1/ICAM mediated cell adhesion
Tocris Bioscience
Discontinued Product
4227 has been discontinued. View all Integrin Receptor Inhibitors products.

Key Product Details

Description

Inhibitor of LFA-1/ICAM mediated cell adhesion
View all Integrin Receptor Inhibitors »

Product Description

RWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).

Product Specifications for RWJ 50271

Molecular Weight

410.41

Formula

C18H17F3N4O2S

Storage

Store at RT

Purity

≥99% (HPLC)

Chemical Name

N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide

CAS Number

162112-37-0

PubChem ID

9953357

InChI Key

HOFGTYCLOKDAES-UHFFFAOYSA-N

SMILES

CC1=C(C(NCCCO)=O)C=NN1C2=NC(C3=CC(C(F)(F)F)=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.04 100
Ethanol 4.1 10

Preparing Stock Solutions for RWJ 50271

The following data is based on the product molecular weight 410.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.18 mL 24.37 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 4 publications citing the usage of this product.

Product Documents for RWJ 50271

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for RWJ 50271

For research use only

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