S 18986

Key Product Details

Product Description

S 18986 is a positive allosteric modulator of AMPA receptors. Exhibits cognitive enhancing properties in rodent behavioral models. Brain penetrant.

Product Specifications for S 18986

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for S 18986

The following data is based on the product molecular weight 224.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	8.92 mL	44.59 mL	89.17 mL
2.5 mM	1.78 mL	8.92 mL	17.83 mL
5 mM	0.89 mL	4.46 mL	8.92 mL
25 mM	0.18 mL	0.89 mL	1.78 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Lockhart (S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide: (S18986-1) a positive modulator of AMPA receptors enhances (S)-AMPA-mediated [3H]noradrenaline release from rat hippocampal and frontal cortex slices. Eur.J.Pharmacol. 2000 PMID: 10924919
• Bourasset Neuropharmacokinetics of a new α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) modulator, S18986 [(S)-2,3-dihydro-[3,4]cyclopentano-1,2,4-benzothiadiazine-1,1-dioxide], in the rat. Drug Metab.Dispos. 2005 PMID: 15860654
• Desos Enantioselective synthesis of a pyrrolo-benzothiadiazine derivative S 18986, a new AMPA receptor positive modulator. Bioorg.Med.Chem.Lett.

Product Documents for S 18986