(S)-Crizotinib

Key Product Details

Product Description

(S)-Crizotinib is a potent MTH1 inhibitor (IC₅₀ = 72 nM). Induces DNA damage and disrupts nucleotide pool homeostasis in cancer cells. Also attenuates colony formation of KRAS-mutated PANC1 cells in vitro. Suppresses tumor growth ~50% in a colon cancer carcinoma xenograft model.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc

Product Specifications for (S)-Crizotinib

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for (S)-Crizotinib

The following data is based on the product molecular weight 450.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.44 mL	22.21 mL	44.41 mL
2.5 mM	0.89 mL	4.44 mL	8.88 mL
5 mM	0.44 mL	2.22 mL	4.44 mL
25 mM	0.09 mL	0.44 mL	0.89 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Huber Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy. Nature 2014 PMID: 24695225

Product Documents for (S)-Crizotinib