(S)-MCPG

Tocris Bioscience | Catalog # 0337

Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)
Tocris Bioscience

Key Product Details

Description

Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)
View all Group I mGluR Antagonists »

Product Description

(S)-MCPG is an active isomer of (RS)-MCPG. Non-selective group I/group II metabotropic glutamate receptor antagonist.

Racemate also available.

Product Specifications for (S)-MCPG

Molecular Weight

209.20

Formula

C10H11NO4

Storage

Store at RT

Purity

≥98% (HPLC)

Chemical Name

(S)-α-Methyl-4-carboxyphenylglycine

CAS Number

150145-89-4

PubChem ID

446355

InChI Key

DNCAZYRLRMTVSF-JTQLQIEISA-N

SMILES

N[C@](C)(C(O)=O)C1=CC=C(C(O)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 20.92 100

Preparing Stock Solutions for (S)-MCPG

The following data is based on the product molecular weight 209.20.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.78 mL 23.90 mL 47.80 mL
5 mM 0.96 mL 4.78 mL 9.56 mL
10 mM 0.48 mL 2.39 mL 4.78 mL
50 mM 0.10 mL 0.48 mL 0.96 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 74 publications citing the usage of this product.

Product Documents for (S)-MCPG

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (S)-MCPG

For research use only

Customer Reviews for (S)-MCPG (1)

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  • (S)-MCPG as a blocker of mGluR action
    Name: Sergiy Sylantyev
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Hippocampus
    Verified Customer | Posted 05/26/2019
    When mGluRs were suppressed with 1 mM (S)-MCPG, NMDAR effect was not enough powerful to generate action potentials in response to repetitive electrical stimulation of neural tissue. Figure: evoked post-synaptic potentials with action potentials (under control) and without action potentials (after application of MCPG.
    (S)-MCPG 0337

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