Salirasib

Tocris Bioscience | Catalog # 4989

Ras inhibitor; also induces autophagy
Tocris Bioscience
Discontinued Product
4989 has been discontinued. View all Ras GTPase Inhibitors products.

Key Product Details

Description

Ras inhibitor; also induces autophagy
View all Ras GTPase Inhibitors »

Product Description

Salirasib is an inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines.

Product Specifications for Salirasib

Molecular Weight

358.54

Formula

C22H30O2S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-yl]thio]benzoic acid

CAS Number

162520-00-5

PubChem ID

5469318

InChI Key

WUILNKCFCLNXOK-CFBAGHHKSA-N

SMILES

C\C(CC/C=C(C)/CC/C=C(C)/C)=C/CSC1=CC=CC=C1C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 35.85 100
1eq. NaOH 17.93 50

Preparing Stock Solutions for Salirasib

The following data is based on the product molecular weight 358.54.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.79 mL 13.95 mL 27.89 mL
5 mM 0.56 mL 2.79 mL 5.58 mL
10 mM 0.28 mL 1.39 mL 2.79 mL
50 mM 0.06 mL 0.28 mL 0.56 mL

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Background References

References are publications that support the biological activity of the product.

Product Documents for Salirasib

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for Salirasib

For research use only

Customer Reviews for Salirasib (1)

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  • Salirasib blocks LPA-mediated COX-2 expression
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Osteosarcoma
    Verified Customer | Posted 12/13/2018
    Human osteosarcoma cells were incubated with 20 μM Salirasib for 30 min prior to treatment with 10 μM LPA to estimate COX-2 expression using Western blot analysis. Salirasib abolished LPA-induced COX-2 expression.
    Salirasib 4989

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