SANT-1

Key Product Details

Product Description

SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (K_D = 1.2 nM). Inhibits smoothened agonist effects with an IC₅₀ of 20 nM (in Shh-LIGHT2 cells). Used in protocols to generate pancreatic β cells from hPSCs (see our protocol below).

For more information about how SANT-1 may be used, see our protocol: Generation of β cells from hPSCs

Product Specifications for SANT-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SANT-1

The following data is based on the product molecular weight 373.50.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	5.35 mL	26.77 mL	53.55 mL
2.5 mM	1.07 mL	5.35 mL	10.71 mL
5 mM	0.54 mL	2.68 mL	5.35 mL
25 mM	0.11 mL	0.54 mL	1.07 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 61 publications citing the usage of this product.

• Chen Small molecule modulation of smoothened activity. Proc.Natl.Acad.Sci.USA.

Product Documents for SANT-1