SB 204070

Key Product Details

Product Description

SB 204070 is a potent and selective 5-HT₄ receptor antagonist (pIC₅₀ = 10.1). Displays >5000-fold selectivity for 5-HT₄ over 5-HT_1A, 5-HT_1D, 5-HT_1E, 5-HT_2A, 5-HT_2C, and 5-HT₃ receptors. Exhibits anxiolytic activity upon systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications for SB 204070

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 204070

The following data is based on the product molecular weight 419.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.38 mL	11.92 mL	23.85 mL
5 mM	0.48 mL	2.38 mL	4.77 mL
10 mM	0.24 mL	1.19 mL	2.38 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Gaster (1-Butyl-4-piperidinyl)methyl 8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride: a highly potent and selective 5-HT₄ antagonist derived from metoclopr. J.Med.Chem. 1993 PMID: 8258837
• Prins An improved in vitro bioassay for the study of 5-HT₄ receptors in the human isolated large intestine circular muscle. Br.J.Pharmacol. 2000 PMID: 10780964
• Bingham Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT₄ receptor function. J.Pharm.Pharmacol. 1995 PMID: 7602484

Product Documents for SB 204070