SB 204741

Key Product Details

Product Description

SB 204741 is a potent and selective 5-HT_2B receptor antagonist (pA₂ = 7.95). Displays ≥ 135-fold selectivity over 5-HT_2C (pK_i = 5.82), 5-HT_2A (pK_i < 5.2), 5-HT_1A, _1D, _1E, 5-HT₃ and 5-HT₄ receptors.

Licensing Information

Sold under license

Product Specifications for SB 204741

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 204741

The following data is based on the product molecular weight 286.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.49 mL	17.46 mL	34.92 mL
5 mM	0.70 mL	3.49 mL	6.98 mL
10 mM	0.35 mL	1.75 mL	3.49 mL
50 mM	0.07 mL	0.35 mL	0.70 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 38 publications citing the usage of this product.

• Ebrahimkhani Stimulating healthy tissue regeneration by targeting the 5-HT_2B receptor in chronic liver disease. Nat.Med. 2011 PMID: 22120177
• Forbes N-(1-Methyl-5-indolyl)-N'-(3-methyl-5-isothiazolyl)urea: a novel, high-affinity 5-HT_2B receptor antagonist. J.Med.Chem. 1995 PMID: 7699699
• Glusa and Pertz Further evidence that 5-HT-induced relaxation of pig pulmonary artery is mediated by endothelial 5-HT_2B receptors. Br.J.Pharmacol. 2000 PMID: 10821800
• Bonhaus The pharmacology and distribution of human 5-hydroxytryptamine_2B (5-HT_2B) receptor gene products: comparison with 5-HT_2A and 5-HT_2C receptors. Br.J.Pharmacol. 1995 PMID: 7582481

Product Documents for SB 204741