SB 242084

Tocris Bioscience | Catalog # 2901

Selective 5-HT2C antagonist; brain penetrant
Tocris Bioscience

Key Product Details

Description

Selective 5-HT2C antagonist; brain penetrant
View all 5-HT2C Receptor Antagonists »

Product Description

SB 242084 is a 5-HT2C receptor antagonist that displays 158- and 100-fold selectivity over 5-HT2A and 5-HT2B receptors respectively. Also displays selectivity over a range of other 5-HT, dopamine and adrenergic receptors. Brain penetrant; exerts anxiolytic-like activity.

Licensing Information

Sold with the permission of GlaxoSmithKline

Product Specifications for SB 242084

Molecular Weight

467.78

Formula

C21H19ClN4O2.2HCl

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridinyl]-1H-indole-1-carboxyamide dihydrochloride

CAS Number

1049747-87-6

PubChem ID

16219981

InChI Key

GCMNSEILNIPNSX-UHFFFAOYSA-N

SMILES

O=C(N3C(C=C(Cl)C(C)=C4)=C4CC3)NC(C=C2)=CN=C2OC1=CC=CN=C1C.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.39 50

Preparing Stock Solutions for SB 242084

The following data is based on the product molecular weight 467.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.28 mL 21.38 mL 42.76 mL
2.5 mM 0.86 mL 4.28 mL 8.55 mL
5 mM 0.43 mL 2.14 mL 4.28 mL
25 mM 0.09 mL 0.43 mL 0.86 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 101 publications citing the usage of this product.

Product Documents for SB 242084

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SB 242084

For research use only

Customer Reviews for SB 242084 (1)

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  • This product is good for in vitro experiment.
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: CHO
    Verified Customer | Posted 06/03/2020
    After reaching 80% confluence, cells were treated with the selective 5-HT2CR antagonist SB242084 (300nM) or the 5-HT1BR antagonist SB216641 (1 µM), applied 10 minutes prior to agonist application.
    300nM
    SB 242084 2901

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