SB 268262

Key Product Details

Product Description

SB 268262 is a selective non-peptide CGRP₁ antagonist. Inhibits [¹²⁵I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC₅₀ values are 0.24 and 0.83 nM respectively).

Licensing Information

Sold with the permission of GlaxoSmithKline.

Product Specifications for SB 268262

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 268262

The following data is based on the product molecular weight 401.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.5 mM	4.98 mL	24.91 mL	49.82 mL
2.5 mM	1.00 mL	4.98 mL	9.96 mL
5 mM	0.50 mL	2.49 mL	4.98 mL
25 mM	0.10 mL	0.50 mL	1.00 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Aiyar Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 2001 PMID: 11181905

Product Documents for SB 268262