SB 674042

Key Product Details

Product Description

SB 674042 is a potent and selective non-peptide orexin OX₁ receptor antagonist (K_d = 3.76 nM). Exhibits 100-fold selectivity for OX₁ over OX₂ receptors. Has no effect at serotonergic, dopaminergic, adrenergic or purinergic receptors. Inhibits orexin 1-induced Ca²⁺ mobilization in CHO-DG44 cells stably transfected with the OX₁ receptor.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline.

Product Specifications for SB 674042

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 674042

The following data is based on the product molecular weight 448.51.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.23 mL	11.15 mL	22.30 mL
5 mM	0.45 mL	2.23 mL	4.46 mL
10 mM	0.22 mL	1.11 mL	2.23 mL
50 mM	0.04 mL	0.22 mL	0.45 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Ellis Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. Biol.Chem. 2006 PMID: 17015451
• Langmead Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br.J.Pharmacol. 2004 PMID: 14691055

Product Documents for SB 674042