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SC 51089

Catalog #: 3758
1 Citation Datasheet / COA / SDS

Discontinued Product

3758 has been discontinued.
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SC 51089 | CAS No. 146033-02-5 | Prostanoid Receptor Antagonists
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Description: Selective EP1 receptor antagonist

Chemical Name: 8-Chlorodibenz(Z)[b,f][1,4]oxazepine-10(11H)-carboxylic acid 2-[1-oxo-3-(4-pyridinyl)propyl]hydrazide hydrochloride

Purity: ≥99%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SC 51089 is a selective EP1 prostanoid receptor antagonist (Ki values are 1.3, 11.2, 17.5, 61.1, > 100, > 100, > 100, >100 and > 100 μM for EP1, TP, EP3, EP2, EP4, FP and DP receptors respectively). Attenuates PGE2-induced neuronal cell death in vitro and slows tumor growth in vivo.

Technical Data

M.Wt:
459.33
Formula:
C22H19ClN4O3.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥99%
Storage:
Store at -20°C
CAS No:
146033-02-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold for research purposes under agreement from Pfizer Inc.

Product Datasheets

Reconstitution Calculator
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Reconstitution Calculator

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Citation for SC 51089

The citations listed below are publications that use Tocris products. Selected citations for SC 51089 include:

1 Citation: Showing 1 - 1

  1. Rat prostaglandin EP3 receptor is highly promiscuous and is the sole prostanoid receptor family member that regulates INS-1 (832/3) cell glucose-stimulated insulin secretion.
    Authors: Sarah E Et al.
    Pharmacol Res Perspect  2021;9:e00736

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