SC 57461A

Name: SC 57461A
Brand: Tocris Bioscience
SKU: 3107
Price: 128 USD

Catalog #: 3107 Datasheet / COA / SDS

Discontinued Product

3107 has been discontinued.

View all Hydrolase Inhibitors products.

SC 57461A | CAS No. 423169-68-0 | Hydrolase Inhibitors

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Description: Selective inhibitor of LTA4 hydrolase

Chemical Name: N-methyl-N-[3-[4-(phenylmethyl)phenoxy]propyl]-β-alanine hydrochloride

Purity: ≥98%

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Product Details

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Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

SC 57461A is a potent and selective inhibitor of LTA₄ hydrolase. Does not inhibit other enzymes of the arachidonic acid cascade including COX-1, COX-2, LTC₄ synthase and 5-lipoxygenase. Potently inhibits LTB₄ production in whole blood (IC₅₀ = 49 nM). Orally active.

Technical Data

M.Wt:

363.88

Formula:

C₂₀H₂₅NO₃.HCl

Solubility:

Soluble to 25 mM in water and to 100 mM in DMSO

Purity:

≥98%

Storage:

Desiccate at +4°C

CAS No:

423169-68-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold for research purposes under agreement from Pfizer Inc.

Background References

The development of novel LTA4H modulators to selectively target LTB4 generation
CM Low, S Akthar, DF Patel, S Löser, CT Wong, PL Jackson, JE Blalock, SA Hare, CM Lloyd, RJ Snelgrove
Sci Rep, 2017;7(0):44449.
Synthesis of potent leukotriene A₄ hydrolase inhibitors. Identification of 3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid.
Penning et al.
J.Med.Chem., 2002;45:3482
Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A₄ hydrolase I: in vitro studies.
Askonas et al.
J.Pharmacol.Exp.Ther., 2002;300:577
Pharmacological characterization of SC-57461A (3-[methyl[3-[4-(phenylmethyl)phenoxy]propyl]amino]propanoic acid HCl), a potent and selective inhibitor of leukotriene A₄ hydrolase II: in vivo studies.
Kachur et al.
J.Pharmacol.Exp.Ther., 2002;300:583

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