SC 79

Tocris Bioscience | Catalog # 4635

Akt activator
Tocris Bioscience

Key Product Details

Description

Akt activator
View all Akt (Protein Kinase B) Activators »

Product Description

SC 79 is an activator of Akt; binds to the pleckstrin homology domain of Akt. Enhances Akt phosphorylation by upstream protein kinases; also enables cytosolic activation of Akt. Shown to suppress excitotoxicity-induced neuronal death in vitro and in vivo. Exhibits brain penetrance.

Product Specifications for SC 79

Molecular Weight

364.78

Formula

C17H17ClN2O5

Storage

Store at -20°C

Chemical Name

2-Amino-6-chloro-α-cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester

CAS Number

305834-79-1

PubChem ID

2810830

InChI Key

DXVKFBGVVRSOLI-UHFFFAOYSA-N

SMILES

NC2=C(C(OCC)=O)C(C(C(OCC)=O)C#N)C1=CC(Cl)=CC=C1O2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 36.48 100

Preparing Stock Solutions for SC 79

The following data is based on the product molecular weight 364.78.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.74 mL 13.71 mL 27.41 mL
5 mM 0.55 mL 2.74 mL 5.48 mL
10 mM 0.27 mL 1.37 mL 2.74 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 44 publications citing the usage of this product.

Product Documents for SC 79

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SC 79

For research use only

Customer Reviews for SC 79 (1)

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  • in vitro teatment
    Name: Anonymous
    Species: Mouse
    Assay Type: In Vitro
    Cell Line/Tissue: BMDM
    Verified Customer | Posted 04/05/2019
    Cells were treated with 5 um SC79 to activate AKT

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