Recombinant Human SCO2 His Protein

Novus Biologicals | Catalog # NBP1-50951

Novus Biologicals
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Key Product Details

Source

E. coli

Tag

His

Applications

SDS-PAGE
View all SCO2 Proteins and Enzymes »

Product Specifications

Description

A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 42-266 of Human SCO2

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGPAETGGQG QPQGPGLRTR LLITGLFGAG LGGAWLALRA EKERLQQQKR TEALRQAAVG QGDFHLLDHR GRARCKADFR GQWVLMYFGF THCPDICPDE LEKLVQVVRQ LEAEPGLPPV QPVFITVDPE RDDVEAMARY VQDFHPRLLG LTGSTKQVAQ ASHSYRVYYN AGPKDEDQDY IVDHSIAIYL LNPDGLFTDY YGRSRSAEQI SDSVRRHMAA FRSVLS

Purity

>90%, by SDS-PAGE

Predicted Molecular Mass

27.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Protein / Peptide Type

Recombinant Protein

Scientific Data Images for Recombinant Human SCO2 His Protein

SDS-PAGE: Recombinant Human SCO2 His Protein [NBP1-50951]

SDS-PAGE: Recombinant Human SCO2 His Protein [NBP1-50951]

SDS-Page: Recombinant Human SCO2 Protein [NBP1-50951] - 15 % SDS-PAGE (3ug)

Formulation, Preparation, and Storage

NBP1-50951
Formulation 20 mM Tris-HCl buffer (pH8.0), 30% glycerol, 2 mM DTT, 200 mM NaCl
Preservative No Preservative
Concentration 0.5 mg/ml
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: SCO2

SCO2 protein belongs to the SCO1/2 family of proteins. Both SCO1 and SCO2 proteins are located on the inner membrane of the mitochondria and plays a crucial role in copper insertion or transport to the active site of cytochrome c oxidase (COX). Defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC). This disease is characterized by hypertrophic cardiomyopathy, lactic acidosis, and gliosis. Heart and skeletal muscle show reductions in cytochrome c oxidase (COX) activity, whereas liver and fibroblasts show mild COX deficiencies. Recombinant human SCO2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Alternate Names

cytochrome oxidase deficient homolog 2, MGC125823, MGC125825, protein SCO2 homolog, mitochondrial, SCO cytochrome oxidase deficient homolog 2 (yeast), yeast) homolog 2

Gene Symbol

SCO2

Additional SCO2 Products

Product Documents for Recombinant Human SCO2 His Protein

Certificate of Analysis

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Product Specific Notices for Recombinant Human SCO2 His Protein

This product is for research use only and is not approved for use in humans or in clinical diagnosis. This product is guaranteed for 1 year from date of receipt.

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