SDZ 205-557 hydrochloride

Name: SDZ 205-557 hydrochloride
Brand: Tocris Bioscience
SKU: 2037

Tocris Bioscience | Catalog # 2037

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Product Documents

5-HT3 and 5-HT4 antagonist

Discontinued Product

2037 has been discontinued. View all 5-HT4 Receptor Antagonists products.

Technical Data
Reviews

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

5-HT3 and 5-HT4 antagonist

View all 5-HT4 Receptor Antagonists »

Product Description

SDZ 205-557 hydrochloride is a 5-HT₃/5-HT₄ receptor antagonist.

Product Specifications for SDZ 205-557 hydrochloride

Molecular Weight

337.25

Formula

C₁₄H₂₁ClN₂O₃.HCl

Storage

Desiccate at RT

Purity

≥99% (HPLC)

Chemical Name

4-Amino-5-chloro-2-methoxybenzoic acid 2-(diethylamino)ethyl ester hydrochloride

CAS Number

1197334-02-3

PubChem ID

11957705

InChI Key

JOWUQCJWCRNVMQ-UHFFFAOYSA-N

SMILES

Cl.CCN(CC)CCOC(=O)C1=CC(Cl)=C(N)C=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	water	33.73	100

Preparing Stock Solutions for SDZ 205-557 hydrochloride

The following data is based on the product molecular weight 337.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.97 mL	14.83 mL	29.65 mL
5 mM	0.59 mL	2.97 mL	5.93 mL
10 mM	0.30 mL	1.48 mL	2.97 mL
50 mM	0.06 mL	0.30 mL	0.59 mL

Calculators

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Mass

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音量

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g/mol

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Background References

References are publications that support the biological activity of the product.

McMahon and Cunningham Antagonism of 5-hydroxytryptamine(4) receptors attenuates hyperactivity induced by cocaine: putative role for 5-hydroxytryptamine(4) receptors in the nucleus accumbens shell. J.Pharmacol.Exp.Ther. 1999 PMID: 10490917
Buchheit SDZ 205-557, a selective, surmountable antagonist for 5-HT4 receptors in the isolated guinea pig ileum. Naunyn-Schmied.Arch.Pharmacol.
Eglen The action of SDZ 205,557 at 5-hydroxytryptamine (5-HT3 and 5-HT4) receptors. Br.J.Pharmacol. 1993 PMID: 8448587

Product Documents for SDZ 205-557 hydrochloride

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for SDZ 205-557 hydrochloride

For research use only

Related Research Areas

The Serotonergic System in Alzheimer's Disease

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