SGX 523

Key Product Details

Product Description

SGX 523 is a potent and selective c-MET kinase inhibitor (IC₅₀ = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.

External Portal Information

Chemicalprobes.org

is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.

Product Specifications for SGX 523

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SGX 523

The following data is based on the product molecular weight 359.41.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	13.91 mL	69.56 mL	139.12 mL
1 mM	2.78 mL	13.91 mL	27.82 mL
2 mM	1.39 mL	6.96 mL	13.91 mL
10 mM	0.28 mL	1.39 mL	2.78 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

• Buchanan SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer.Ther. 2009 PMID: 19934279

Product Documents for SGX 523