SIB 1893

Key Product Details

Product Description

SIB 1893 is an a highly selective non-competitive antagonist for the metabotropic glutamate mGlu₅ receptor subtype; displays an IC₅₀ value of 0.3 μM at hmGlu₅, compared with > 100 μM at hmGlu_1b, hmGlu₂, hmGlu₆, hmGlu₇ and hmGlu₈. Centrally active upon systemic administration in vivo. Positive allosteric modulator at mGlu₄ receptors.

Product Specifications for SIB 1893

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SIB 1893

The following data is based on the product molecular weight 195.26.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	5.12 mL	25.61 mL	51.21 mL
5 mM	1.02 mL	5.12 mL	10.24 mL
10 mM	0.51 mL	2.56 mL	5.12 mL
50 mM	0.10 mL	0.51 mL	1.02 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.

• Mathiesen Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. Br.J.Pharmacol. 2003 PMID: 12684257
• Varney SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5. J.Pharmacol.Exp.Ther. 1999 PMID: 10381773
• Chapman Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). Neuropharmacology 2000 PMID: 10854901

Product Documents for SIB 1893