Sinomenine hydrochloride

Key Product Details

Product Description

Natural anti-inflammatory morphinan analog. Causes degranulation of mast cells in mammalian tissues to release histamine and suppresses production of proinflammatory cytokines. Also displays antinociceptive activity, possibly through activation of the μ-opioid receptor. Stimulates short-term renewal of human embryonic stem cells (ESCs) in vitro.

Product Specifications for Sinomenine hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Sinomenine hydrochloride

The following data is based on the product molecular weight 365.85.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.73 mL	13.67 mL	27.33 mL
5 mM	0.55 mL	2.73 mL	5.47 mL
10 mM	0.27 mL	1.37 mL	2.73 mL
50 mM	0.05 mL	0.27 mL	0.55 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Qian Sinomenine, a natural dextrorotatory morphinan analog, is anti-inflammatory and neuroprotective through inhibition of microglial NADPH oxidase. J.Neuroinflamm.
• Desbordes High-throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2008 PMID: 18522853
• Wang Activation of opioid μ-receptor by sinomenine in cell and mice. Neurosci.Lett. 2008 PMID: 18692550
• Yamasaki Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum. Acta Med.Okayama 1976 PMID: 61710

Product Documents for Sinomenine hydrochloride