Sipatrigine

Key Product Details

Product Description

Sipatrigine is a blocker of voltage-dependent sodium channels (Na_V). Inhibits glutamate release; displays neuroprotective activity in rat models of cerebral ischemia. Also thought to block Ca²⁺ channels. Analog of lamotrigine (Cat. No. 1611).

Product Specifications for Sipatrigine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Sipatrigine

The following data is based on the product molecular weight 372.68.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.68 mL	13.42 mL	26.83 mL
5 mM	0.54 mL	2.68 mL	5.37 mL
10 mM	0.27 mL	1.34 mL	2.68 mL
50 mM	0.05 mL	0.27 mL	0.54 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Graham Neuroprotective effects of a use-dependent blocker of voltage-dependent sodium channels, BW619C89, in rat middle cerebral artery occlusion. J.Pharmacol.Exp.Ther. 1994 PMID: 7910213
• Stefani On the inhibition of voltage activated calcium currents in rat cortical neurones by the neuroprotective agent 619C89. Br.J.Pharmacol. 1998 PMID: 9846645
• Leach BW619C89, a glutamate release inhibitor, protects against focal cerebral ischemic damage. Stroke 1993 PMID: 8100654

Product Documents for Sipatrigine