SirReal 2

Tocris Bioscience | Catalog # 5457

Selective inhibitor of SIRT2
Tocris Bioscience

Key Product Details

Description

Selective inhibitor of SIRT2
View all Class III Histone Deacetylases Inhibitors »

Product Description

SirReal 2 is a selective SIRT2 inhibitor (IC50 = 140 nM). Has minimal effect on SIRT1 and SIRT3-6. Increases α-tubulin acetylation levels in HeLa cells.

Product Specifications for SirReal 2

Molecular Weight

420.55

Formula

C22H20N4OS2

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-[(4,6-Dimethyl-2-pyrimidinyl)thio]-N-[5-(1-naphthalenylmethyl)-2-thiazolyl]acetamide

CAS Number

709002-46-0

PubChem ID

1096292

InChI Key

MENNDDDTIIZDDN-UHFFFAOYSA-N

SMILES

CC1=CC(C)=NC(SCC(NC2=NC=C(CC3=CC=CC4=C3C=CC=C4)S2)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.05 100

Preparing Stock Solutions for SirReal 2

The following data is based on the product molecular weight 420.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.89 mL 23.78 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

Product Documents for SirReal 2

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SirReal 2

For research use only

Customer Reviews for SirReal 2 (1)

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  • test
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Du145 and HepG2, Huh&
    Verified Customer | Posted 02/21/2025
    We treated cultured cells with a concentration of 20 µM for 24-48 hours, followed by protein extraction and analysis of cell growth.
    SirReal 2 5457

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