SJ 11646

Tocris Bioscience | Catalog # 7721

Potent and selective LCK Degrader (PROTAC®)
Tocris Bioscience

Key Product Details

Description

Potent and selective LCK Degrader (PROTAC®)
View all Active Degraders »

Product Description

SJ 11646 is a potent LCK (lymphocyte-specific protein tyrosine kinase) Degrader (PROTAC®; DC50 = 0.00838 pM). It comprises Dasatinib (Cat. No. 6793), as the LCK ligand, and a phenyl glutarimide-based cereblon binder. It shows cytotoxicity in LCK-activated T cell acute lymphoblastic leukemia (T-ALL) cell lines and primary leukemia samples in vitro. In vivo, SJ11646 shows anti-leukemic efficacy in patient-derived xenograft models of T-ALL.

LCK antibodies validated for Simple Western™ (automated Western) instruments and Western Blot also available: Catalog # AF3704 and MAB37041.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Licensing Information

Sold under license from St. Jude Children's Research Hospital.

Product Specifications for SJ 11646

Molecular Weight

746.28

Formula

C36H40ClN9O5S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(2-Chloro-6-methylphenyl)-2-((6-(4-(3-(2-(4-(2,6-dioxopiperidin-3-yl)phenoxy)acetamido)propyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide

CAS Number

2933135-82-9

InChI Key

AJNQGWOQPRWRML-UHFFFAOYSA-N

SMILES

CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCCNC(COC5=CC=C(C=C5)C6CCC(NC6=O)=O)=O)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 14.93 20

Preparing Stock Solutions for SJ 11646

The following data is based on the product molecular weight 746.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.2 mM 6.70 mL 33.50 mL 67.00 mL
1 mM 1.34 mL 6.70 mL 13.40 mL
2 mM 0.67 mL 3.35 mL 6.70 mL
10 mM 0.13 mL 0.67 mL 1.34 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

x
=
x

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Background References

References are publications that support the biological activity of the product.

Product Documents for SJ 11646

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SJ 11646

For research use only

Customer Reviews for SJ 11646

There are currently no reviews for this product. Be the first to review SJ 11646 and earn rewards!

Have you used SJ 11646?

Submit a review and receive an Amazon gift card!

$25/€18/£15/$25CAN/¥2500 Yen for a review with an image

$10/€7/£6/$10CAN/¥1110 Yen for a review without an image

Submit a review
Amazon Gift Card