SJFα

Tocris Bioscience | Catalog # 7268

Potent and selective p38α PROTAC®
Tocris Bioscience

Key Product Details

Description

Potent and selective p38α PROTAC®

Alternative Names

SJFa PROTAC,SJFalpha PROTAC,SJFα PROTAC
View all Active Degraders »

Product Description

SJFα is a potent and selective p38α PROTAC® Degrader (DC50 = 7.16 nM; Dmax = 97.4%). SJFα comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Displays significantly lower potency degradation at p38δ (DC50 = 299 nM). Exhibits no significant degradation of p38β, p38γ or related MAPKs, ERK1/2, or JNK1/2.

p38γ antibodies validated for Simple Western™ (automated Western) instruments also available: Catalog # AF1347 and MAB1347.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Product Specifications for SJFα

Molecular Weight

1120.28

Formula

C59H67F2N7O11S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-(3-Fluoro-4-((7-(4-(4-(2-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-2-oxoethoxy)butoxy)butoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide

CAS Number

2254609-27-1

PubChem ID

137628677

InChI Key

GXDYWQXTEYENEU-WFYKIECOSA-N

SMILES

COC1=CC2=C(N=CC=C2OC3=C(C=C(C=C3)NC(C4(C(NC5=CC=C(C=C5)F)=O)CC4)=O)F)C=C1OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N6C[C@@H](C[C@H]6C(NCC7=CC=C(C8=C(N=CS8)C)C=C7)=O)O)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 112.03 100

Preparing Stock Solutions for SJFα

The following data is based on the product molecular weight 1120.28.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.89 mL 4.46 mL 8.93 mL
5 mM 0.18 mL 0.89 mL 1.79 mL
10 mM 0.09 mL 0.45 mL 0.89 mL
50 mM 0.02 mL 0.09 mL 0.18 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SJFα

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SJFα

For research use only

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