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SKF 82958 hydrobromide

Catalog #: 5719
1 Citation Datasheet / COA / SDS

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SKF 82958 hydrobromide | CAS No. 74115-01-8 | Dopamine D1 and D5 Receptor Antagonists
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Description: D1 agonist

Chemical Name: 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propen-1-yl)-1H-3-benzazepine-7,8-diol hydrobromide

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SKF 82958 hydrobromide is a D1 agonist. Increases renal blood flow in animal models and promotes contralateral rotation in rats with unilateral lesions of the substantia nigra. Also augments GABAB inhibitory post-synaptic potentials (ipsp) in ventral tegmental area in brain slices.

Technical Data

M.Wt:
410.73
Formula:
C19H20ClNO2.HBr
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in water with gentle warming
Purity:
≥98%
Storage:
Store at RT
CAS No:
74115-01-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. DArgic activity of substituted 6-chloro-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines.
    Pfeiffer et al.
    J.Med.Chem., 1982;25:352
  2. DA D1 receptors facilitate transmitter release.
    Cameron and Williams
    Nature, 1993;366:344

Product Datasheets

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Citation for SKF 82958 hydrobromide

The citations listed below are publications that use Tocris products. Selected citations for SKF 82958 hydrobromide include:

1 Citation: Showing 1 - 1

  1. Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making.
    Authors: Verharen Et al.
    Neuropsychopharmacology  2019;44:2195

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