SKPin C1

Tocris Bioscience | Catalog # 4817

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
Tocris Bioscience
Discontinued Product
4817 has been discontinued. View all Ubiquitin Ligase (E3) Inhibitors products.

Key Product Details

Description

Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
View all Ubiquitin Ligase (E3) Inhibitors »

Product Description

SKPin C1 is an inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.

Product Specifications for SKPin C1

Molecular Weight

465.34

Formula

C18H13BrN2O4S2

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid

CAS Number

432001-69-9

PubChem ID

5733396

InChI Key

IYCJJVVXEHZJHE-CHHVJCJISA-N

SMILES

BrC1=CC=C(OCC(O)=O)C(/C=C2\SC(N(CC3=CN=CC=C3)C2=O)=S)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.65 10

Preparing Stock Solutions for SKPin C1

The following data is based on the product molecular weight 465.34.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.49 mL 107.45 mL 214.90 mL
0.5 mM 4.30 mL 21.49 mL 42.98 mL
1 mM 2.15 mL 10.74 mL 21.49 mL
5 mM 0.43 mL 2.15 mL 4.30 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Product Documents for SKPin C1

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SKPin C1

For research use only

Related Research Areas

E3 Ubiquitin Ligases

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