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SKPin C1

Catalog #: 4817
2 Citations Datasheet / COA / SDS

Discontinued Product

4817 has been discontinued.
View all Ubiquitin Ligase (E3) Inhibitors products.
SKPin C1 | CAS No. 432001-69-9 | Ubiquitin Ligase (E3) Inhibitors
1 Image
Description: Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest

Chemical Name: 2-[4-Bromo-2-[[4-oxo-3-(3-pyridinylmethyl)-2-thioxo-5-thiazolidinylidene]methyl]phenoxy]acetic acid

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SKPin C1 is an inhibitor of Skp2-mediated p27 degradation. Induces p27 accumulation in metastatic melanoma cell lines. Promotes G1/S cell cycle arrest in T47D cells and LNCaP cells; induces G2/M cell cycle arrest in MCF-7 cells.

Technical Data

M.Wt:
465.34
Formula:
C18H13BrN2O4S2
Solubility:
Soluble to 10 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
432001-69-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for SKPin C1

The citations listed below are publications that use Tocris products. Selected citations for SKPin C1 include:

2 Citations: Showing 1 - 2

  1. Identification of highly penetrant Rb-related synthetic lethal interactions in triple negative breast cancer.
    Authors: Brough Et al.
    Oncogene  2018;
  2. Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling.
    Authors: Kramer Et al.
    J Neurosci  2016;36:10425

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