SL 327

Key Product Details

Product Description

SL 327 is a selective inhibitor of MEK1 and MEK2 (IC₅₀ values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

Product Specifications for SL 327

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SL 327

The following data is based on the product molecular weight 335.35.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.98 mL	14.91 mL	29.82 mL
5 mM	0.60 mL	2.98 mL	5.96 mL
10 mM	0.30 mL	1.49 mL	2.98 mL
50 mM	0.06 mL	0.30 mL	0.60 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 77 publications citing the usage of this product.

• Atkins The MAPK cascade is required for mammalian associative learning. Nature Neurosci. 1998 PMID: 10196568
• Scherle Regulation of cyclooxygenase-2 induction in the mouse uterus during decidualization. An event of early pregnancy. J.Biol.Chem. 2000 PMID: 10969080
• Wang Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J.Pharmacol.Exp.Ther. 2003 PMID: 12490588
• Davis The MAPK/ERK cascade targets both Elk-1 and cAMP response element-binding protein to control long-term potentiation-dependent gene expression in the dentate gyrus in vivo. J.Neurosci. 2000 PMID: 10844026

Product Documents for SL 327