SMANT hydrochloride

Key Product Details

Product Description

SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism. Inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC₅₀ = 1.1 μM). Inhibits both wild-type Smo and an oncogenic form (SmoM2) with similar efficacy.

Product Specifications for SMANT hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SMANT hydrochloride

The following data is based on the product molecular weight 375.73.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.66 mL	13.31 mL	26.61 mL
5 mM	0.53 mL	2.66 mL	5.32 mL
10 mM	0.27 mL	1.33 mL	2.66 mL
50 mM	0.05 mL	0.27 mL	0.53 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Wang Selective identification of Hedgehog pathway antagonists by direct analysis of Smoothened ciliary translocation. ACS Chem.Biol. 2012 PMID: 22554036

Product Documents for SMANT hydrochloride