SNDX-5613

Tocris Bioscience | Catalog # 8907

Menin-MLL interaction inhibitor
Tocris Bioscience
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Key Product Details

Description

Menin-MLL interaction inhibitor

Alternative Names

Revumenib
View all Lysine Methyltransferase Inhibitors »

Product Description

SNDX-5613 is a potent inhibitor of menin-MLL1 protein-protein interaction (Ki = 0.149 nM; IC50 = 10-20 nM). Orally bioavailable.

Product Specifications for SNDX-5613

Molecular Weight

630.82

Formula

C32H47FN6O4S

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

N-Ethyl-2-[[4-[7-[[trans-4-[(ethylsulfonyl)amino]cyclohexyl]methyl]-2,7-diazaspiro[3.5]non-2-yl]-5-pyrimidinyl]oxy]-5-fluoro-N-(1-methylethyl)benzamide

CAS Number

2169919-21-3

PubChem ID

132212657

InChI Key

FRVSRBKUQZKTOW-YOCNBXQISA-N

SMILES

CC(N(C(C1=CC(F)=CC=C1OC2=C(N=CN=C2)N3CC4(C3)CCN(CC4)C[C@@H]5CC[C@H](CC5)NS(CC)(=O)=O)=O)CC)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 31.54 50
Ethanol 12.62 20

Preparing Stock Solutions for SNDX-5613

The following data is based on the product molecular weight 630.82.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 3.17 mL 15.85 mL 31.70 mL
2.5 mM 0.63 mL 3.17 mL 6.34 mL
5 mM 0.32 mL 1.59 mL 3.17 mL
25 mM 0.06 mL 0.32 mL 0.63 mL

Calculators

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Background References

References are publications that support the biological activity of the product.

Product Documents for SNDX-5613

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SNDX-5613

For research use only

Related Research Areas

Epigenetics
Lysine Methyltransferases

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