Sonepiprazole

Key Product Details

Product Description

Sonepiprazole is a selective, high affinity antagonist for the rat and human dopamine D₄ receptor (K_i = 10 nM). Exhibits low affinity at other monoamine receptors (K_i > 2000 nM). Induces c-fos gene expression in medial prefrontal cortex in a similar manner to clozapine (Cat. No. 0444). Brain penetrant and orally available.

Licensing Information

Sold for research purposes under agreement from Pfizer Inc.

Product Specifications for Sonepiprazole

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Sonepiprazole

The following data is based on the product molecular weight 401.52.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.49 mL	12.45 mL	24.91 mL
5 mM	0.50 mL	2.49 mL	4.98 mL
10 mM	0.25 mL	1.25 mL	2.49 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 3 publications citing the usage of this product.

• Merchant Pharmacological characterization of U-101387, a DA D₄ receptor selective antagonist. J.Pharmacol.Exp.Ther. 1996 PMID: 8968364

Product Documents for Sonepiprazole