Chemical Name: 4-[4-[[[[4-Chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methyl-2-pyridinecarboxamide
Biological ActivitySorafenib is a potent Raf inhibitor (IC50 values are 6, 22 and 38 nM for Raf-1, wild-type BRAF and V599E BRAF mutant, respectively). Also inhibits mVEGFR-2, mVEGFR-3, mPDGFR-β, Flt-3, cKIT and VEGFR-2 (IC50 values are 15, 20, 57, 58, 68 and 90 nM, respectively). Inhibits MAPK pathway in colon, pancreatic and breast cancer cells expressing mutant KRAS and mutant or wt BRAF in vitro. Exhibits antitumor activity in colon, breast and non small-cell lung cancer xenograft models. Also induces ferroptosis in hepatocellular carcinoma cells in vitro.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis.
Wilhelm et al.
Cancer Res., 2004;64:7099
Sorafenib induces ferroptosis in human cancer cell lines originating from different solid tumors.
Lachaier et al.
Anticancer Res., 2014;34:6417
Citation for Sorafenib
The citations listed below are publications that use Tocris products. Selected citations for Sorafenib include:
1 Citation: Showing 1 - 1
Effect of CRISPR Knockout of AXIN1 or ARID1A on Proliferation and Migration of Porcine Hepatocellular Carcinoma.
Authors: Grace Et al.
Front Oncol 2022;12:904031
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