SP 100030

Tocris Bioscience | Catalog # 5309

NF-κB and AP-1 dual inhibitor
Tocris Bioscience

Key Product Details

Description

NF-κB and AP-1 dual inhibitor
View all NFkB/IkB Inhibitors »

Product Description

SP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.

Product Specifications for SP 100030

Molecular Weight

437.65

Formula

C14H5ClF9N3O

Storage

Store at +4°C

Purity

≥98% (HPLC)

Chemical Name

N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide

CAS Number

154563-54-9

PubChem ID

9910975

InChI Key

GHMKQBWHPQMXSH-UHFFFAOYSA-N

SMILES

O=C(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C1=C(C(F)(F)F)N=C(Cl)N=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 43.76 100
Ethanol 43.76 100

Preparing Stock Solutions for SP 100030

The following data is based on the product molecular weight 437.65.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.28 mL 11.42 mL 22.85 mL
5 mM 0.46 mL 2.28 mL 4.57 mL
10 mM 0.23 mL 1.14 mL 2.28 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 7 publications citing the usage of this product.

Product Documents for SP 100030

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SP 100030

For research use only

Customer Reviews for SP 100030 (1)

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  • Jurkat T cell inhibition
    Name: Anonymous
    Species: Human
    Assay Type: In Vitro
    Cell Line/Tissue: Jurkat
    Verified Customer | Posted 10/28/2021
    Used on Jurkat cell line, to inhibit cell activation after stimulation with PMA/PHA, at a dose of 50ng/mL
    SP 100030 5309

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