Chemical Name: N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide
Biological ActivitySP 100030 is a potent dual inhibitor of NF-κB and AP-1 transcriptional activity (IC50 = 50 nM). Blocks production of IL-2, IL-8 and TNF-α from Jurkat T cells. Inhibits cytokine production selectively in T cells; exhibits minimal inhibition of cytokine production in other cell types. Decreases arthritic severity in a mouse model of collagen-induced arthritis. Also ameliorates muscle wasting in a rat model of cancer cachexia.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
The effect of a T cell-specific NF-κB inhibitor on in vitro cytokine production and collagen-induced arthritis
Gerlag et al.
2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'- bis(trifluoromethyl)phenyl)-carboxamide: a potent inhibitor of NF-κB- and AP-1-mediated gene expression identified using solution-phase combinatorial ch
Sullivan et al.
The AP-1/NF-κB double inhibitor SP100030 can revert muscle wasting during experimental cancer cachexia.
Moore-Carrasco et al.
Citations for SP 100030
The citations listed below are publications that use Tocris products. Selected citations for SP 100030 include:
2 Citations: Showing 1 - 2
Tumor-Derived Lysophosphatidic Acid Blunts Protective Type I Interferon Responses in Ovarian Cancer.
Authors: David Et al.
Cancer Discov 2022;12:1904-1921
TAK1 inhibition in mouse astrocyte cultures ameliorates cytokine-induced chemokine production and neutrophil migration.
Authors: Stephen Et al.
J Neurochem 2020;152:697-709
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Used on Jurkat cell line, to inhibit cell activation after stimulation with PMA/PHA, at a dose of 50ng/mL