Spexin

Tocris Bioscience | Catalog # 6090

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Citations (5)

Product Documents

Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

Product Description
Product Specifications
Solubility
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Potent GAL2/3 agonist; exhibits anxiolytic effects in vivo

Alternative Names

NPQ,Neuropeptide Q

View all Galanin Receptor Agonists »

Product Description

Spexin is a potent galanin receptor 2/3 (GAL₂/GAL₃) agonist (EC₅₀ values are 45.7 and 112.2 nM, respectively). Exhibits no significant activity at galanin receptor 1. Endogenous satiety-inducing peptide; inhibits long chain fatty acid uptake by adipocytes and decreases food consumption in diet-induced obese mice and rats. Attenuates LH secretion in goldfish. Exhibits anxiolytic effects in vivo.

Product Specifications for Spexin

Molecular Weight

1619.90

Formula

C₇₄H₁₁₄N₂₀O₁₉S

Storage

Store at -20°C

Purity

≥95% (HPLC)

CAS Number

1370290-58-6

PubChem ID

122705996

InChI Key

ZZDZBDJTNIOJMF-TWMPYRTRSA-N

SMILES

[H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1mg/ml in water

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 5 publications citing the usage of this product.

Reyes-Alcaraz Development of spexin-based human galanin receptor type II-specific agonists with increased stability in serum and anxiolytic effect in mice. Sci.Rep. 2016 PMID: 26907960
Kim Coevolution of the spexin/galanin/kisspeptin family: Spexin activates galanin receptor type II and III. Endocrinology 2014 PMID: 24517231
Walewski Spexin is a novel human peptide that reduces adipocyte uptake of long chain fatty acids and causes weight loss in rodents with diet-induced obesity Obesity (Silver Spring) 2014 PMID: 24550067

Product Documents for Spexin

Certificate of Analysis

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Product Specific Notices for Spexin

For research use only

Related Research Areas

Metabolic Peptide Hormones and Regulators

Citations for Spexin

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