Home / 5-HT2A Receptor Antagonists / Spiperone hydrochloride

Spiperone hydrochloride

Catalog #: 0995
6 Citations Datasheet / COA / SDS

Discontinued Product

0995 has been discontinued.
View all 5-HT2A Receptor Antagonists products.
Spiperone hydrochloride | CAS No. 2022-29-9 | 5-HT2A Receptor Antagonists
1 Image
Description: 5-HT2A antagonist; also D2-like antagonist

Chemical Name: 8-[4-(4-Fluorophenyl)-4-oxobutyl]-1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one hydrochloride

Purity: ≥98%

Product Details
Citations (6)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Spiperone hydrochloride is a 5-HT2A serotonin and selective D2-like dopamine receptor antagonist (Ki values are 0.06, 0.6, 0.08, ~ 350, ~ 3500 nM for D2, D3, D4, D1 and D5 receptors respectively). Antipsychotic.

Technical Data

M.Wt:
431.94
Formula:
C23H26FN3O2.HCl
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at RT
CAS No:
2022-29-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
    Fox JT, Sakamuru S, Huang R
    Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
  2. VII. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin).
    Hoyer et al.
    Pharmacol.Rev., 1994;46:157
  3. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Spiperone hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for Spiperone hydrochloride include:

6 Citations: Showing 1 - 6

  1. Oncotoxic Properties of Serotonin Transporter Inhibitors and 5-HT1A Receptor Ligands.
    Authors: Walory Et al.
    Int J Mol Sci  2018;19
  2. Pharmacological analysis of DA modulation in the Drosophila melanogaster larval heart.
    Authors: Titlow Et al.
    Physiol Rep  2013;1:e00020
  3. Gene-environment interactions affect long-term depression (LTD) through changes in DA receptor affinity in Snap25 deficient mice.
    Authors: Baca Et al.
    Brain Res  2013;1532:85
  4. DArgic agonists that result in ocular growth inhibition also elicit transient increases in choroidal thickness in chicks.
    Authors: Nickla Et al.
    Exp Eye Res  2010;91:715
  5. Regulation of DA transporter function and cell surface expression by D3 DA receptors.
    Authors: Zapata Et al.
    J Biol Chem  2007;282:35842
  6. DA targets cycling B cells independent of receptors/transporter for oxidative attack: Implications for non-Hodgkin's lymphoma.
    Authors: Meredith Et al.
    Proc Natl Acad Sci U S A  2006;103:13485

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Spiperone hydrochloride

There are currently no reviews for this product. Be the first to review Spiperone hydrochloride and earn rewards!

Have you used Spiperone hydrochloride?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.