Spiroxatrine

Key Product Details

Product Description

Spiroxatrine is a 5-HT_1A antagonist. More active and selective than spiperone. Also a very potent α_2C adrenergic receptor antagonist.

Product Specifications for Spiroxatrine

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Spiroxatrine

The following data is based on the product molecular weight 379.46.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.35 mL	131.77 mL	263.53 mL
0.5 mM	5.27 mL	26.35 mL	52.71 mL
1 mM	2.64 mL	13.18 mL	26.35 mL
5 mM	0.53 mL	2.64 mL	5.27 mL

Calculators

Background References

References are publications that support the biological activity of the product.

• Nelson and Taylor Spiroxatrine: a selective serotonin 1A receptor antagonist. Eur.J.Pharmacol. 1986 PMID: 3720840
• Schoeffter and Hoyer Centrally acting hypotensive agents with affinity for 5-HT_1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br.J.Pharmacol. 1988 PMID: 3207999
• Bylund Pharmacological characteristics of α₂-adrenergic receptors: comparison of pharmacologically defined subtypes with subtypes identified by molecular cloning. Mol.Pharmacol. 1992 PMID: 1353247

Product Documents for Spiroxatrine