SR 1078

Key Product Details

Product Description

SR 1078 is an agonist of retinoic acid receptor-related orphan receptors (ROR) RORα/γ. Increases transcription of RORα target genes; thought to increase p53 stability.

Licensing Information

Sold under license from The Scripps Research Institute.

Product Specifications for SR 1078

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SR 1078

The following data is based on the product molecular weight 431.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.59 mL	23.19 mL
5 mM	0.46 mL	2.32 mL	4.64 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 12 publications citing the usage of this product.

• Wang Regulation of p53 stability and apoptosis by a ROR agonist. PLoS One 2012 PMID: 22509368
• Wang Identification of a synthetic agonist for the orphan nuclear receptors RORα and RORγ, SR1078. ACS Chem.Biol. 2010 PMID: 20735016

Product Documents for SR 1078