SR 141716A

Tocris Bioscience | Catalog # 0923

Selective CB1 inverse agonist
Tocris Bioscience

Key Product Details

Description

Selective CB1 inverse agonist

Alternative Names

Rimonabant hydrochloride
View all Cannabinoid R1 / CB1 Inverse Agonists »

Product Description

SR 141716A is a potent and selective cannabinoid CB1 receptor antagonist (Ki = 1.98 nM). Also acts as an inverse agonist reversing adenylyl cyclase inhibition by WIN 55,212-2 (Cat.No. 1038) (IC50 = 48 nM). Displays no activity at CB2 receptors. Reduces food intake and body weight in orally dosed non-obese Wistar rats. Also μ-opioid receptor antagonist (Ki = 652 nm)

Product Specifications for SR 141716A

Molecular Weight

500.25

Formula

C22H21Cl3N4O.HCl

Storage

Desiccate at RT

Purity

≥98% (HPLC)

Chemical Name

N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide hydrochloride

CAS Number

158681-13-1

PubChem ID

104849

InChI Key

REOYOKXLUFHOBV-UHFFFAOYSA-N

SMILES

O=C(NN4CCCCC4)C1=NN(C3=CC=C(Cl)C=C3Cl)C(C2=CC=C(Cl)C=C2)=C1C.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 50.02 100

Preparing Stock Solutions for SR 141716A

The following data is based on the product molecular weight 500.25.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.00 mL 10.00 mL 19.99 mL
5 mM 0.40 mL 2.00 mL 4.00 mL
10 mM 0.20 mL 1.00 mL 2.00 mL
50 mM 0.04 mL 0.20 mL 0.40 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 132 publications citing the usage of this product.

Product Documents for SR 141716A

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SR 141716A

For research use only

Customer Reviews for SR 141716A (2)

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  • Rimonabant treatment in mice
    Name: Sebastiaan Dalle
    Species: Mouse
    Assay Type: In Vivo
    Verified Customer | Posted 05/24/2023
    Rimonabant stock was prepared in dmso and tween80, and consequently freshly diluted with saline.
    10mg/kg body weight, dissolved in solution with 6.7% dmso, 1.7% tween80 and 91.6% saline; intraperitoneally injected.
    SR 141716A 0923
  • Highly recommend.
    Name: Anonymous
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: Bed nucleus of the stria terminalis
    Verified Customer | Posted 06/01/2020
    SR 141716A was solubilized in DMSO and bath applied at a 5 micromolar concentration. It effectively blocked CB1-receptor-dependent long term depression of evoked excitatory postsynaptic current in the bed nucleus of the stria terminalis.
    SR 141716A 0923

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