Chemical Name: 2-[[[5-(2,6-Dimethoxyphenyl)-1-[4-[[[3-(dimethylamino)propyl]methylamino]carbonyl]-2-(1-methylethyl)phenyl]-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[22.214.171.124,7]decane-2-carboxylic acid
Biological ActivitySR 142948 is a potent non-peptide neurotensin (NT) receptor antagonist that binds with high affinity (IC50 = 0.32 - 3.96 nM; Ki < 10 nM). Attenuates amphetamine-induced hyperactivity and is orally active in vivo.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist.
Gully et al.
X-ray structural characterization of SR 142948, a novel potent synthetic neurotensin receptor antagonist.
Quere et al.
Effects of the selective neurotensin antagonist SR 142948A on 3,4-methylenedioxymethamphetamine-induced behaviours in mice.
Marie-Claire et al.
Citations for SR 142948
The citations listed below are publications that use Tocris products. Selected citations for SR 142948 include:
4 Citations: Showing 1 - 4
Ventral Midbrain NTS1 Receptors Mediate Conditioned Reward Induced by the Neurotensin Analog, D-Tyrneurotensin.
Authors: Rouibi Et al.
J Cereb Blood Flow Metab 2016;9:470
Neurotensin Induces Presynaptic Depression of D2 DA Autoreceptor-Mediated Neurotransmission in Midbrain DArgic Neurons.
Authors: Piccart Et al.
J Neurosci 2015;35:11144
Dependence of Relative Expression of NTR1 and EGFR on Cell Density and Extracellular pH in Human Pancreatic Cancer Cell Lines.
Authors: Olszewski-Hamilton and Hamilton
Cancers (Basel) 2011;3:182
Neurotensin reduces glutamatergic transmission in the dorsolateral striatum via retrograde endocannabinoid signaling.
Authors: Yin Et al.
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