SR 2211

Tocris Bioscience | Catalog # 4869

Selective RORγ inverse agonist
Tocris Bioscience

Key Product Details

Description

Selective RORγ inverse agonist
View all ROR / NR1F Inverse Agonists »

Product Description

SR 2211 is a selective inverse agonist of retinoic acid receptor-related orphan receptor γ (RORγ) (Ki = 105 nM; IC50 ~320 nM). Exhibits weak activity at liver X receptor α (LXRα); does not affect the transcriptional activity of farnesoid X receptors (FXR), and has no impact on the transcriptional activity of RORα.

Licensing Information

Sold under license from The Scripps Research Institute.

Product Specifications for SR 2211

Molecular Weight

527.48

Formula

C26H24F7N3O

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol

CAS Number

1359164-11-6

PubChem ID

51035449

InChI Key

KVHKWAZUPPBMLL-UHFFFAOYSA-N

SMILES

FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 52.75 100

Preparing Stock Solutions for SR 2211

The following data is based on the product molecular weight 527.48.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.90 mL 9.48 mL 18.96 mL
5 mM 0.38 mL 1.90 mL 3.79 mL
10 mM 0.19 mL 0.95 mL 1.90 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

Calculators

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 14 publications citing the usage of this product.

Product Documents for SR 2211

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for SR 2211

For research use only

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